报告题目：Optimization and Variability of Stochastic Pharmacokinetic model induced by drug non-adherence

报告人：吴孝钿教授，上海海事大学

报告时间：2025年10月24日（周五）15:00-16:00

报告地点：20-202

报告摘要：In this talk, I will present a stochastic pharmacokinetic model induced by drug non-adherence, including random dosing times and random dosages. Our aim in this work is to analyze how dual-randomness affects drug concentration variability, and to develop dosage adjustment strategies for the desired concentration. Leveraging the renewal process, the law of total expectation, and the theory of second-type Volterra integral equations, the statistical properties of drug concentrations under general distributions in dosing times and dosages are derived. Given specific uniform and exponential distributions of inter-dose time intervals, we developed the explicit expressions of statistical characteristics, and the dosage adjustment strategies to acquire the desired concentration are theoretically proposed and designed. The findings in this work establish a theoretical foundation for understanding drug concentration variability within a dual-randomness framework, thereby providing critical insights for risk prevention and process control in drug therapy during disease treatment.

报告人简介：吴孝钿，上海海事大学理学院教授，博士生导师，2013年加拿大约克大学应用数学专业理学博士，曾在加拿大西安大略大学应用数学系和蒙特利尔大学药学院从事博士后研究。主要从事经虫媒传播的传染病动力学建模、分析和预测，以及基于数据和药理的药物动力学建模、分析和模拟。在环境科学、药学和生物数学的EHP、JPKPD、JMB、JTB、MBs和BMB等知名学术期刊发表论文40多篇。先后主持完成国家自然科学基金青年项目和境外加拿大自然科学与工程基金博士后项目（FRQNT）。目前主持国家自然科学基金面上项目和上海市重点课程建设项目，曾获上海海事大学学科竞赛活动优秀指导教师一等奖。

邀请人：动力系统与非线性分析研究所